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Publications

2018

Jia S, Miedel MT, Ngo M, Hessenius R, Chen N, Wang P, Bahreini A, Li Z, Ding Z, Shun TY, Zuckerman DM, Taylor DL, Puhalla SL, Lee AV, Oesterreich S, Stern AM. Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes. Oncology. 2018 Jan 6;94(3):176-189. doi: 10.1159/000485510. PubMed PMID: 29306943.

Chen J, Nagle AM, Wang YF, Boone DN, Lee AV. Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveal shared and distinct activities of holo and hybrid receptors. J Biol Chem. 2018 Jan 12. pii: jbc.M117.789503. doi: 10.1074/jbc.M117.789503.PubMed PMID: 29330302.

Hartmaier RJ, Trabucco SE, Priedigkeit N, Chung JH, Parachoniak CA, Vanden Borre P, Morley S, Rosenzweig M, Gay LM, Goldberg ME, Suh J, Ali S, Ross J, Leyland-Jones B, Young B, Williams C, Park B, Tsai M, Haley B, Peguero J, Callahan RD, Sachelarie I, Cho J, Atkinson JM, Bahreini A, Nagle AM, Puhalla SL,  Watters RJ, Erdogan-Yildirim Z, Cao L, Oesterreich S, Mathew A, Lucas PC, Davidson NE, Brufsky AM, Frampton GM, Stephens PJ, Chmielecki J, Lee AV. Recurrent hyperactive ESR1 fusion proteins in endocrine therapy resistant breast  cancer. Ann Oncol. 2018 Jan 19. doi: 10.1093/annonc/mdy025. [Epub ahead of print] PubMed PMID: 29360925.

Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee AV, Omberg L, Wolf DM, Shriver CD, Thorsson V; Cancer Genome Atlas Research Network, Hu H. An Integrated TCGA Pan-Cancer Clinical Data  Resource to Drive High-Quality Survival Outcome Analytics. Cell. 2018 Apr 5;173(2):400-416.e11. doi: 10.1016/j.cell.2018.02.052. PubMed PMID: 29625055.

Müller S, Agnihotri S, Shoger KE, Myers MI, Smith N, Chaparala S, Villanueva CR, Chattopadhyay A, Lee AV, Butterfield LH, Diaz A, Okada H, Pollack IF, Kohanbash G. Peptide vaccine immunotherapy biomarkers and response patterns in pediatric gliomas. JCI Insight. 2018 Apr 5;3(7). pii: 98791. doi: 10.1172/jci.insight.98791. [Epub ahead of print] PubMed PMID: 29618666.

Luthra S, Chandran U, Diergaarde B, Becich M, Lee AV, Neumann CA. Expression of reactive species related genes is associated with patient survival in luminal B breast cancer. Free Radic Biol Med. 2018 Mar 12;120:170-180. doi: 10.1016/j.freeradbiomed.2018.03.011. [Epub ahead of print] PubMed PMID: 29545070.

2017

Li Z, Levine KM, Bahreini A, Wang P, Chu D, Park BH, Oesterreich S, Lee AV. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells. Endocrinology. 2018 Jan 1;159(1):285-296. doi: 10.1210/en.2017-00693. PubMed PMID: 29029116.

Andersen CL, Sikora MJ, Boisen MM, Ma T, Christie A, Tseng G, Park YS, Luthra S, Chandran U, Haluska P, Mantia-Smaldone G, Odunsi K, McLean K, Lee AV, Elishaev E, Edwards RP, Oesterreich S. Active estrogen receptor-alpha signaling in ovarian cancer models and clinical specimens. Clin Cancer Res. 2017 Jan 10. pii: clincanres.1501.2016. doi: 10.1158/1078-0432.CCR-16-1501. PMID: 28073843

Panebianco F, Kelly LM, Liu P, Zhong S, Dacic S, Wang X, Singhi AD, Dhir R, Chiosea SI, Kuan SF, Bhargava R, Dabbs D, Trivedi S, Gandhi M, Diaz R, Wald AI, Carty SE, Ferris RL, Lee AV, Nikiforova MN, Nikiforov YE. THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.
Proc Natl Acad Sci U S A. 2017 Feb 13. PMID: 28193878

Jankowitz RC, Oesterreich S, Lee AV, Davidson NE. New Strategies in Metastatic Hormone Receptor-Positive Breast Cancer: Searching for Biomarkers to Tailor Endocrine and Other Targeted Therapies. Clin Cancer Res. 2017 Mar 1;23(5):1126-1131. doi: 10.1158/1078-0432.CCR-16-0591. Epub 2016 Dec 15. PubMed PMID: 27979914; PubMed Central PMCID: PMC5350010.

Zhang M, Lee AV, Rosen JM. The Cellular Origin and Evolution of Breast Cancer. Cold Spring Harb Perspect Med. 2017 Mar 1;7(3). pii: a027128. doi: 10.1101/cshperspect.a027128. Review. PubMed PMID: 28062556.

Priedigkeit N, Hartmaier RJ, Chen Y, Vareslija D, Basudan A, Watters RJ, Thomas R, Leone JP, Lucas PC, Bhargava R, Hamilton RL, Chmielecki J, Puhalla SL, Davidson NE, Oesterreich S, Brufsky AM, Young L, Lee AV. Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases. JAMA Oncol. 2017 May 1;3(5):666-671. doi: 10.1001/jamaoncol.2016.5630. PubMed PMID: 27926948; PubMed Central PMCID: PMC5508875.

Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S. Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models. Breast Cancer Res. 2017 May 23;19(1):60. doi: 10.1186/s13058-017-0851-4. PubMed PMID: 28535794; PubMed Central PMCID: PMC5442865.

Nguyen L, Tosun AB, Fine JL, Lee AV, Taylor DL, Chennubhotla SC. Spatial Statistics for Segmenting Histological Structures in H&E Stained Tissue Images. IEEE Trans Med Imaging. 2017 Jul;36(7):1522-1532. doi: 10.1109/TMI.2017.2681519. Epub 2017 Mar 16. PubMed PMID: 28328502; PubMed Central PMCID: PMC5498226.

Priedigkeit N, Watters RJ, Lucas PC, Basudan A, Bhargava R, Horne W, Kolls JK, Fang Z, Rosenzweig MQ, Brufsky AM, Weiss KR, Oesterreich S, Lee AV. Exome-capture RNA sequencing of decade-old breast cancers and matched decalcified bone metastases. JCI Insight. 2017 Sep 7;2(17). pii: 95703. doi: 10.1172/jci.insight.95703. PubMed PMID: 28878133; PubMed Central PMCID: PMC5621874.

Budiu RA, Vlad AM, Nazario L, Bathula C, Cooper KL, Edmed J, Thaker PH, Urban J, Kalinski P, Lee AV, Elishaev EL, Conrads TP, Flint MS. Restraint and Social Isolation Stressors Differentially Regulate Adaptive Immunity and Tumor Angiogenesis in a Breast Cancer Mouse Model. Cancer Clin Oncol. 2017 May;6(1):12-24. doi: 10.5539/cco.v6n1p12. Epub 2016 Nov 11. PubMed PMID: 28603578; PubMed Central PMCID: PMC5464739.

Spagnolo DM, Al-Kofahi Y, Zhu P, Lezon TR, Gough A, Stern AM, Lee AV, Ginty F, Sarachan B, Taylor DL, Chennubhotla SC. Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images. Cancer Res. 2017 Nov 1;77(21):e71-e74. doi: 10.1158/0008-5472.CAN-17-0676. PubMed PMID: 29092944; PubMed Central PMCID: PMC5683175.

Ekambaram P, Lee JL, Hubel NE, Hu D, Yerneni S, Campbell PG, Pollock N, KleiLR, Concel VJ, Delekta PC, Chinnaiyan AM, Tomlins SA, Rhodes DR, Priedigkeit N, Lee AV, Oesterreich S, McAllister-Lucas L, Lucas PC. The CARMA3-Bcl10-MALT1 Signalosome Drives NF-κB Activation and Promotes Aggressiveness in Angiotensin II Receptor-positive Breast Cancer. Cancer Res. 2017 Dec 19. pii: canres.1089.2017. doi: 10.1158/0008-5472.CAN-17-1089. PubMed PMID: 29259013.

2016

Wang P, Bahreini A, Gyanchandani R, Lucas PC, Hartmaier RJ, Watters RJ, Jonnalagadda AR, Trejo Bittar HE, Berg A, Hamilton RL, Kurland BF, Weiss KR, Mathew A, Leone JP, Davidson NE, Nikiforova MN, Brufsky AM, Ambros TF, Stern AM, Puhalla SL, Lee AV, Oesterreich S. Sensitive detection of mono- and polyclonal ESR1 mutations in primary tumors, metastatic lesions and cell free DNA of breast cancer patients. Clin Cancer Res. 2016 Mar 1;22(5):1130-7. doi: 10.1158/1078-0432.CCR-15-1534.92) Gurda GT, Ambros T, Nikiforova MN, Nikiforov YE, Lucas PC, Dabbs DJ, Lee AV, Brufsky AM, Puhalla SL, Bhargava R. Characterizing Molecular Variants and Clinical Utilization of Next-generation Sequencing in Advanced Breast Cancer. Appl Immunohistochem Mol Morphol. 2016 Feb 9. [Epub ahead of print]

Becker MA, Ibrahim YH, Oh AS, Fagan DH, Byron SA, Sarver AL, Lee AV, Shaw LM, Fan C, Perou CM, Yee D. Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer. PLoS One. 2016 Mar 18;11(3):e0150564. doi: 10.1371/journal.pone.0150564. eCollection 2016. PMID: 26991655.

Kim SH, Kaschula CH, Priedigkeit N, Lee AV, Singh SV. Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide. J Biol Chem. 2016 Jun 24;291(26):13495-508. doi: 10.1074/jbc.M116.715219. Epub 2016 Apr 29. PMID: 27129776
Gyanchandani R, Lin Y, Lin HM, Cooper KL, Normolle DP, Brufsky AM, Fastuca M, Crosson W, Oesterreich S, Davidson NE, Bhargava R, Dabbs DJ, Lee AV. Intra-tumor heterogeneity affects gene expression profile test prognostic risk stratification in early breast cancer. Clin Cancer Res. 2016 Nov 1;22(21):5362-5369.PMID: 27185370

Erdem C, Nagle AM, Casa AJ, Litzenburger BC, Wang YF, Taylor DL, Lee AV*, Lezon TR*. Proteomic screening and lasso regression reveal differential signaling in insulin and insulin-like growth factor I pathways. Mol Cell Proteomics. 2016 Jun 30. pii: mcp.M115.057729. PMID: 27364358 (* shared senior author)

Gyanchandani R, Kota KJ, Jonnalagadda AR, Minteer T, Knapick BA, Oesterreich S, Brufsky AM, Lee AV, Puhalla SL. Detection of ESR1 mutations in circulating cell-free DNA from patients with metastatic breast cancer treated with palbociclib and letrozole. Oncotarget. 2016 Aug 19. doi: 10.18632/oncotarget.11383. PMID: 27556863

Sikora MJ, Johnson MD, Lee AV, Oesterreich S. Endocrine response phenotypes are altered by charcoal-stripped serum variability. Endocrinology. 2016 Jul 26:en20161297. PMID: 27459541

Chandran UR, Medvedeva OP, Barmada MM, Blood PD, Chakka A, Luthra S, Ferreira A, Wong KF, Lee AV, Zhang Z, Budden R, Scott JR, Berndt A, Berg JM, Jacobson RS TCGA Expedition: A Data Acquisition and Management System for TCGA Data. PLoS One. 2016 Oct 27;11(10):e0165395. doi: 10.1371/journal.pone.0165395.PMID: 27788220100) Farabaugh SM, Chan BT, Cui X, Dearth RK, Lee AV. Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer. Cell Commun Signal. 2016 Oct 21;14(1):25. PMID: 27765041 3.

Lu S, Cai C, Yan G, Zhou Z, Wan Y, Chen V, Chen L, Cooper GF, Obeid LM, Hannun YA, Lee AV, Lu X.
Signal-oriented pathway analyses reveal a signaling complex as a synthetic lethal target for p53 mutations. Cancer Res. 2016 Oct 10. pii: canres.1740.2016. PMID: 27758891

Sikora MJ, Jacobsen BM, Levine K, Chen J, Davidson NE, Lee AV, Alexander CM, Oesterreich S. WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. Breast Cancer Res. 2016 Sep 20;18(1):92. doi: 10.1186/s13058-016-0748-7. PMID: 27650553 

Onuchic V, Hartmaier RJ, Boone DN, Samuels ML, Patel RY, White WM, Garovic VD, Oesterreich S, Roth ME, Lee AV, Milosavljevic A. Epigenomic Deconvolution of Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types. Cell Rep. 2016 Nov 15;17(8):2075-2086. doi: 10.1016/j.celrep.2016.10.057.
PMID: 27851969

Bahreini A, Levine K, Santana-Santos L, Benos P, Wang P, Andersen C, Oesterreich S, Lee AV. Non-coding single nucleotide variants affecting estrogen receptor binding and activity. Genome Medicine. Genome Med. 2016 Dec 13;8(1):128.

Priedigkeit N, Hartmaier RJ, Chen Y, Vareslija D, Basudan A, Watters RJ, Thomas R, Leone JP, Lucas PC,  Bhargava R, Hamilton RL, Chmielecki J, Puhalla SL, Davidson NE, Oesterreich S, Brufsky AM, Young L, Lee AV. Breast cancer brain metastases show limited intrinsic subtype switching, yet exhibit acquired ERBB2 amplifications and activating mutations. JAMA Oncol. 2016 Dec 7. doi: 10.1001/jamaoncol.2016.5630

Spagnolo DM, Gyanchandani R, Al-Kofahi Y, Stern AM, Lezon TR, Gough A, Meyer DE, Ginty F, Sarachan B, Fine J, Lee AV, Taylor DL and Chennubhotla SC. Pointwise mutual information quantifies intra-tumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers. J Pathol Inform. 2016 Nov 29;7:47

2015

Jiang S, Katz TA, Garee JP, DeMayo FJ, Lee AV, Oesterreich S.  Scaffold attachment factor B2 (SAFB2) null mice reveal non-redundant functions compared to its paralog SAFB1. Dis Model Mech. 2015 Jun 18. pii: dmm.019885. PMID: 26092125

Nayak SR, Harrington E, Boone D, Hartmaier R, Chen J, Pathiraja TN, Cooper KL, Fine JL, Sanfilippo J, Davidson NE, Lee AV, Dabbs D, Oesterreich S.  A Role for Histone H2B Variants in Endocrine-Resistant Breast Cancer. Horm Cancer. 2015 Jun 26. PMID: 26113056 
Cooper GF, Bahar I, Becich MJ, Benos PV, Berg J, Espino JU, Glymour C, Jacobson RC, Kienholz M, Lee AV, Lu X, Scheines R; Center for Causal Discovery team. The Center for causal discovery of biomedical knowledge from Big Data. J Am Med Inform Assoc. 2015 Jul 2. pii: ocv059. doi: 10.1093/jamia/ocv059. PMID: 26138794

Leone JP, Bhargava R, Theisen BK, Hamilton RL, Lee AV, Brufsky AM. Expression of high affinity folate receptor in breast cancer brain metastasis. Oncotarget. 2015 Jun 25. [Epub ahead of print] PMID: 26160847 
Liao S, Hartmaier RJ, McGuire KP, Puhalla SL, Luthra S, Chandran UR, Ma T, Bhargava R, Modugno F, Davidson NE, Benz S, Lee AV, Tseng GC, Oesterreich S.  The molecular landscape of premenopausal breast cancer.  Breast Cancer Res. 2015 Aug 7;17:104. doi: 10.1186/s13058-015-0618-8. PMID: 26251034

Casa AJ, Hochbaum D, Sreekumar S, Oesterreich S, Lee AV. The estrogen receptor alpha nuclear localization sequence is critical for fulvestrant-induced degradation of the receptor. Mol Cell Endocrinol. 2015 Aug 10. pii: S0303-7207(15)30047-2. doi: 10.1016/j.mce.2015.08.007. [Epub ahead of print] PMID: 26272024

Brown DD, Dabbs DJ, Lee AV, McGuire KP, Ahrendt GM, Bhargava R, Davidson NE, Brufsky AM, Johnson RR, Oesterreich S, McAuliffe PF.  Developing in vitro models of human ductal carcinoma in situ from primary tissue explants. Breast Cancer Res Treat. 2015 Aug 18. PMID: 26283301

Katz TA, Liao S, V Palmieri,, Dearth RK, Pathiraja TN, Huo Z, Shaw P, Small S, Davidson NE, Peters DG, Tseng G,  Oesterreich S, and Lee AV. Targeted DNA methylation screen in the mouse mammary genome reveals a parity-induced hypermethylation of IGF1R which persists long after parturition.  Cancer Prev Res (Phila). 2015 Oct;8(10):1000-9. doi: 10.1158/1940-6207.CAPR-15-0178. Epub 2015 Aug 19

Liu S, Tsai WH, Ding Y, Chen R, Fang Z, Huo Z, Kim S, Ma T, Chang TY, Priedigkeit NM, Lee AV, Luo J, Wang HW, Chung IF, Tseng GC.  Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data. Nucleic Acids Res. 2015 Nov 17. pii: gkv1234. PMID: 26582927 

2014

Fu X, Creighton CJ, Biswal NC, Kumar V, Shea M, Herrera S, Contreras A, Gutierrez C, Wang T, Nanda S, Giuliano M, Morrison G, Nardone A, Karlin KL, Westbrook TF, Heiser LM, Anur P, Spellman P, Guichard SM, Smith PD, Davies BR, Klinowska T, Lee AV, Mills GB, Rimawi MF, Hilsenbeck SG, Gray JW, Joshi A, Osborne C, Schiff R.  Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.  Breast Cancer Res. 2014 Sep 11;16(5):430. 

Coarfa C, Pichot C, Jackson A, Tandon A, Amin V, Raghuraman S, Paithankar S, Lee AV, McGuire SE, Milosavljevic A.  Analysis of interactions between the epigenome and structural mutability of the genome using Genboree Workbench tools.  BMC Bioinformatics. 2014;15 Suppl 7:S2. doi: 10.1186/1471-2105-15-S7-S2.

Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL. Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.  PLoS One. 2014 Jul 18;9(7):e102678. doi: 10.1371/journal.pone.0102678. eCollection 2014.  PMID: 25036749

Leone JP, Lee AV, Brufsky AM.  Prognostic factors and survival of patients with brain metastasis from breast cancer who underwent craniotomy.  Cancer Med. 2015 Jul;4(7):989-94. doi: 10.1002/cam4.439

Pathiraja TN, Nayak SR, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ, Gannon F, Kangaspeska S, Jelinek J, Issa JP, Richer JK, Elias A, McIlroy M, Young LS, Davidson NE, Schiff R, Li W, Oesterreich S.  Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer.  Sci Transl Med. 2014 Mar 26;6(229):229ra41. doi: 10.1126/scitranslmed.3008326.  PMID: 24670685

2012

Wang J, Ray PS, Sim MS, Zhou XZ, Lu KP, Lee AV, Lin X, Bagaria SP, Giuliano AE, Cui X FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling.  Oncogene. 2012 Nov 8;31(45):4798-802.

Potter AS, Casa AJ, Lee AV.  Forkhead box A1 (FOXA1) is a key mediator of insulin-like growth factor I (IGF-I) activity.  J Cell Biochem. 2012 Jan;113(1):110-21. PMID: 21882221


2011

Dearth RK, Kuiatse I, Wang YF, Liao L, Hilsenbeck SG, Brown PH, Xu J, Lee AV. A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis. BMC Cancer. 2011 Aug 25;11(1):377. PMID: 21867536 
Casa AJ, Potter AS, Malik S, Lazard Z, Kuiatse I, Kim HT, Tsimelzon A, Creighton CJ, Hilsenbeck SG, Brown PH, Oesterreich S, Lee AV.  Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth.  Breast Cancer Res Treat. 2011 May 4. PMID: 21541704

Hartmaier RJ, Richter AS, Gillihan RM, Sallit JZ, McGuire SE, Wang J, Lee AV, Osborne CK, O'Malley BW, Brown PH, Xu J, Skaar TC, Philips S, Rae JM, Azzouz F, Li L, Hayden J, Henry NL, Nguyen AT, Stearns V, Hayes DF, Flockhart DA, Oesterreich S.  A SNP in Steroid Receptor Coactivator-1 Disrupts a GSK3β Phosphorylation Site and Is Associated with Altered Tamoxifen Response in Bone.  Mol Endocrinol. 2011 Dec 15. PMID: 2217437

Hampton OA, Miller CA, Koriabine M, Li J, Den Hollander P, Carbone L, Nefedov M, Ten Hallers BF, Lee AV, De Jong PJ, Milosavljevic A.  Long-range massively parallel mate pair sequencing detects distinct mutations and similar patterns of structural mutability in two breast cancer cell lines.  Cancer Genet. 2011 Aug;204(8):447-57.  PMID: 21962895

Qu Y, Wang J, Ray PS, Guo H, Huang J, Shin-Sim M, Bukoye BA, Liu B, Lee AV, Lin X, Huang P, Martens JW, Giuliano AE, Zhang N, Cheng NH, Cui X.  Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling.  J Clin Invest. 2011 Jan 4;121(1):212-25.  PMID: 21123948

Becker MA, Ibrahim YH, Cui X, Lee AV, Yee D.  The IGF Pathway Regulates ER{alpha} through a S6K1-Dependent Mechanism in Breast Cancer Cells.  2011 Mar;25(3):516-28. Epub 2011 Feb 3.

2010

Hassan AA, Chan TB, Hartman KB, Ananta JS, Mackeyev Y, Hu L, Pautler RG, Wilson LJ, Lee AV. Serine-Derivatized Gadonanotubes as Magnetic Nanoprobes for Intracellular Labeling of Breast Cancer Cells.  Contrast Media and Molecular Imaging. 2010 Jan;5(1):34-8.

Wang J, Kuiatse I, Lee AV, Pan J, Giuliano A, Cui X.  Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation.  Mol Cancer Res. 2010 Feb;8(2):266-77.

Dearth RK, Delgado DA, Hiney JK, Pathiraja T, Oesterriech S, Medina D, Dees LW and Lee AV.  Parity-induced reduction in circulating growth hormone (GH) is associated with altered mammary gland signaling in two rat strains: Implications for pregnancy protection from breast cancer. Cancer Prevention Res. 2010 Mar;3(3):312-21.

Migliaccio I, Wu MF, Gutierrez C, Malorni L, Mohsin SK, Allred DC, Hilsenbeck SG, Osborne CK, Weiss H, Lee AV.  Nuclear IRS-1 predicts tamoxifen response in patients with early breast cancer.  Breast Cancer Res Treat. 2010 Oct;123(3):651-60. PMID: 19924529

Powers GL, Ellison-Zelski SJ, Casa AJ, Lee AV, Alarid ET.  Proteasome inhibition represses ERalpha gene expression in ER+ cells: a new link between proteasome activity and estrogen signaling in breast cancer.  Oncogene. 2010 Mar 11;29(10):1509-18. PMID: 19946334

Creighton CJ,  Fu X, Hennessy BT, Casa AJ, Zhang Y, Gonzalez-Angulo AM, Lluch A, Gray JW, Brown PH, Hilsenbeck SG, Osborne CK, Mills GB, Lee AV, Schiff R.   Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer. Breast Cancer Res. 2010;12(3):R40. PMID: 20569503

Gualberto A, Dolled-Filhart M, Gustavson M, Christiansen J, Wang YF, Hixon ML, Reynolds J, McDonald S, Ang A, Rimm DL, Langer CJ, Blakely J, Garland L, Paz-Ares LG, Karp DD, Lee AV.  Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition.  Clin Cancer Res. 2010 Sep 15;16(18):4654-65.  PMID: 20670944

2009

Litzenburger BC, Kim H-J, Kuiatse I, Carboni JM, Attar RM, Gottardis MM, Fairchild CR, and Lee AV.  BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF-7 cells.  Clin Cancer Res 2009; 15: 226-37. PMID: 19118050

Hampton OA, Den Hollander P, Miller CA, Delgado DA, Li J, Coarfa C, Harris RA, Richards S, Scherer SE, Muzny DM, Gibbs RA, Lee AV, Milosavljevic A. A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome. Genome Res. 2009;19:167-77. PMID: 19056696 [Featured on the front cover of the Science section of the New York Times, Dec 25th, 2008]

Kaipparettu BA, Dobrzycka KM, Britton O, Lee AV, Herron AJ, Li Y, Lewis MT, Medina D, Oesterreich S. Scaffold attachment factor B1 (SAFB1) heterozygosity does not collaborate with Wnt-1 or DMBA induced tumorigenesis. Mol Cancer. 2009; 8:15. PMID: 1926789
Liu S, Umezu-Goto M, Murph M, Lu Y, Liu W, Zhang F, Yu S, Stephens LC, Cui X, Murrow G, Coombes K, Muller W, Hung MC, Perou CM, Lee AV, Fang X, Mills GB.  Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.  Cancer Cell. 2009 Jun 2;15(6):539-50

Mackeyev Y, Hartman KB, Ananta JS, Lee AV, Wilson LJ.  Catalytic synthesis of amino acid and peptide derivatized gadonanotubes.  J Am Chem Soc. 2009 Jun 24;131(24):8342-3.

Malik S, Jiang S, Garee JP, Verdin E, Lee AV, O'Malley BW, Zhang M, Belaguli NS, Oesterreich S.  HDAC7 and FoxA1 in estrogen-mediated repression of RPRM.  Mol Cell Biol. 2009 ;30(2):399-412.

2008

Gatza CE, Dumble M, Kittrell F, Edwards DG, Dearth RK, Lee AV, Xu J, Medina D, Donehower LA.  Altered mammary gland development in the p53+/m mouse, a model of accelerated aging.  Developmental Biology, 313:130-41, 2008

Abraham Kaipparettu B, Kuiatse I, Tak-Yee Chan B, Benny Kaipparettu M, Lee AV, Oesterreich S.  Novel egg white-based 3-D cell culture system. Biotechniques 45:165-71. 2008. PMID: 18687065

Creighton CJ, Casa A, Lazard Z, Huang S, Tsimelzon A, Hilsenbeck SG, Osborne CK, and Lee AV.  Insulin-like growth factor I (IGF-I) activates gene transcription programs strongly associated with poor breast cancer prognosis.  J Clin Oncol, 26:4078-85. 2008. PMID: 18757322
Ibrahim YH, Byron SA, Cui X, Lee AV, Yee D.  Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2.  Mol Cancer Res. 6:1491-8, 2008.  PMID: 188199

2007

Kim HJ, Litzenburger BC, Cui X, Delgado, DA, Grabiner BC, Lin X, Lewis MT, Gottardis MM, Wong TW, Attar RM, Carboni J, and Lee AV. Constitutively active IGF-IR causes transformation and xenograft growth of immortalized mammary epithelial cells, and is accompianed by an epithelial to mesenchymal transition mediated by NF-kappaB and snail. Molecular and Cellular Biology, 27:3165-75, 2007.

Hadsell DL, Olea W, Lawrence N, George J, Torres D, Kadowaki T, Lee AV. Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.  Journal of Endocrinology, 194:327-36, 2007.

Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM. Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Developmental Biology, 309:137-49, 2007.
DeNardo DG, Cuba VL, Kim H, Wu K, Lee AV, Brown PH.  Estrogen receptor DNA binding is not required for estrogen-induced breast cell growth. Molecular and Cellular Endocrinology, 277:13-25, 2007

2006

Singleton DW, Feng Y, Yang J, Puga A, Lee AV, Khan SA. Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environmental Research, 100:86-92, 2006.

Divisova J, Kuiatse I, Lazard Z, Weiss H, Vreeland F, Hadsell DL, Schiff R, Osborne CK, Lee AV. The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth. Breast Cancer Research and Treatment, 98:315-27, 2006.

Cui X, Kim HJ, Kuiatse I, Kim H, Brown PH, Lee AV. Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH(2)-terminal kinase/activator protein-1 signaling to regulate cell migration. Cancer Research, 66:5304-13, 2006.

Liao L, Dearth RK, Zhou S, Britton OL, Lee AV, Xu J. Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency. Endocrinology, 147:3877-88, 2006.

Dobrzycka KM, Kang K, Jiang S, Meyer R, Rao PH, Lee AV, Oesterreich S. Disruption of Scaffold Attachment Factor B1 Leads to TBX2 Up-regulation, Lack of p19ARF Induction, Lack of Senescence, and Cell Immortalization. Cancer Research, 66:7859-63, 2006

Townson SM, Kang K, Lee AV, Oesterreich S. Novel role of the RET finger protein in estrogen receptor-mediated transcription in MCF-7 cells. Biochemical and Biophysical Research Communications, 349:540-8, 2006.

Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV. Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Molecular and Cellular Biology, 26:9302-14, 2006.

Maor S, Mayer D, Yarden RI, Lee AV, Sarfstein R, Werner H, Papa MZ. Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: Involvement of transcription factor Sp1. Journal of Endocrinology, 191:605-12, 2006.

2005

Arpino G, Weiss H, Lee AV, Schiff R, De Placido S, Osborne CK, Elledge RM. Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance. Journal of the National Cancer Institute, 97:1254-61, 2005.

Carboni JM, Lee AV, Hadsell DL, Rowley BR, Lee FY, Bol DK, Camuso AE, Gottardis M, Greer AF, Ho CP, Hurlburt W, Li A, Saulnier M, Velaparthi U, Wang C, Wen M-L, Westhouse RA, Wittman M, Zimmerman K, Rupnow BA, Wong TW. Tumor development by transgenic expression of a constitutively active insulin-like growth factor-1 receptor. Cancer Research, 65:3781-7, 2005.

Ivanova M, Dobrzycka KM, Jiang S, Michaelis K, Meyer R, Kang K, Adkins B, Barski OA, Divisova J, Lee AV, Oesterreich S. Scaffold attachment factor SAFB1 functions in development, growth, and reproduction. Molecular and Cellular Biology, 25:2995-3006, 2005.

Hadsell DL, Torres DT, Lawrence NA, George J, Parlow AF, Lee AV, Fiorotto ML. Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation. Biology of Reproduction, 73:1116-25, 2005.

2004

Sachdev D, Hartell JS, Lee AV, Zhang X, Yee D. A dominant negative type I insulin-like growth factor-1 receptor inhibits metastasis of human cancer cells. Journal of Biological Chemistry, 279:5017-24, 2004.

Fowler AM, Solodin N, Preisler-Mashek MT, Zhang P, Lee AV, Alarid ET. Increases in estrogen receptor- concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen. FASEB Journal, 18:81-93, 2004.

Kuang SQ, Liao L, Zhang H, Lee AV, O'Malley BW, Xu J. AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Research, 64:1875-85, 2004.

Townson SM, Kang K, Lee AV, Oesterreich S. Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: Identification of a potent transcriptional repression domain. Journal of Biological Chemistry, 279:26074-81, 2004

Singleton DW, Feng Y, Chen Y, Busch SJ, Lee AV, Puga A, Khan SA. Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Molecular and Cellular Endocrinology, 221:47-55, 2004.

2003

Hovey RC, Harris J, Hadsell DL, Lee AV, Ormandy CJ, Vonderhaar BK. Local insulin-like growth factor-II mediates prolactin-induced mammary gland development. Molecular Endocrinology, 17:460-71, 2003.

Cui X, Zhang P, Deng W, Oesterreich S, Lu Y, Mills GB, and Lee AV. IGF-I inhibits progesterone receptor expression in breast cancer cells via the PI3K/Akt/mTOR pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer. Molecular Endocrinology, 17:575-588, 2003.

Townson S, Deng W, Dobrzycka KM,  Air M, Lee AV, Kang K, Jiang S, Michaelis K, Oesterreich S. SAFB2 – A New SAFB homolog and estrogen receptor corepressor. Journal of Biological Chemistry, 278:20059-68, 2003.

Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen JM, Grimm S, Hovey RC, Vonderhaar BK, Kahn CR ,Torres D, George J, Mohsin S, Allred DC, and Hadsell DL.  Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.  Endocrinology, 144:2683-94, 2003.

Oesterreich S, Deng W, Jiang S, Cui X, Ivanova M, Schiff R, Kang K, Hadsell DL, Behrens J, and Lee AV. Estrogen-mediated downregulation of E-Cadherin in breast cancer cells. Cancer Research, 63:5203-5208, 2003.

Cui X, Lazard Z, Zhang P, Hopp T, Oesterreich S, Lee AV. Progesterone potentiates insulin receptor substrate 2 signals in breast cancer cells. Oncogene, 22:6937-41, 2003.

Lee AV, Taylor ST, Greenall J, Mills JD, Tonge DW, Zhang P, George J, Fiorotto ML, and Hadsell D. Rapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in mice. Hormone and Metabolic Research, 35:651-5, 2003.

2002

Hadsell D, Bonnette S and Lee AV.  Genetic manipulation of the IGF-I axis to regulate mammary gland development and function.  Journal of Dairy Science, 85:1-13, 2002.

Grimm S, Seagroves T, Kabotyanski  E, Hovey R, Vonderhaar BK, Lydon JP, Miyoshi K, Henrighausen L, Ormandy CJ, Lee AV, Stull M, Wood, TA, Rosen JM. Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Molecular Endocrinology, 16:2675-91, 2002.

2001

Oesterreich S, Allred DC, Lee AV, Osborne CK, O’Connell P. High rates of loss of heterozygosity on chromosome 19p13 in breast cancer.  British Journal of Cancer, 84:1-6, 2001.

Hadsell DL, Alexeenko T, Klemintidis Y, Torres D, Lee AV.  Inability of overexpressed des (1-3 human IGF-I to inhibit forced mammary gland involution is associated with decreased expression of IGF signaling molecules.  Endocrinology, 142:1479-1488, 2001.

Feliers D, Duch J, Stewart JL, Lee AV, Abboud HE, Ghosh-Choudhury G, Kasinath BS. Activation of signaling pathways of db/db mice with type 2 diabetes.  Kidney International, 60:495-504, 2001.

Oesterreich S, Zhang P, Guler RL, Sun X, Curran EM, Welshons WV, Osborne CK, Lee AV.  Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and IGF-mediated signaling and growth.  Cancer Research, 61:5771-7, 2001.

Thordarson G, Lee AV, McCarty M, Van Horn K, Chu O, Chou Y, Yang J, Guzman R, Nandi S, Talamates F. Growth and characterization of N-methyl-N-nitrosourea-induced mammary tumors in intact and ovariectomized rats.  Carcinogenesis, 22:2039-2047, 2001.

2000

Lee AV, Gooch JL, Oesterreich S, Guler RL, Yee D. Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition. Molecular and Cellular Biology, 20:1489-96, 2000.

Oesterreich S, Zhang Q, Hopp T, Fuqua SAW, Michaelis M, Dallas S, Yang L, Brown P, Zhao H, Davie JR, Mohsin S, Allred DC, Osborne CK, Lee AV.  Tamoxifen-bound estrogen receptor strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of estrogen receptor-mediated transactivation.  Molecular Endocrinology, 14:369-381, 2000.

Townson S, Sullivan T, Zhang QP, Yee D, Clark GM, Osborne CK, Lee AV, Oesterreich S.  HET/SAF-B overexpression causes growth arrest and multinuclearity and is associated with aneuploidy in human breast cancer.  Clinical Cancer Research, 6:3788-96, 2000.

1999

Lee AV, Jackson JG, Gooch JL, Hilsenbeck SG, Coronado-Heinsohn E, Osborne CK, Yee D. Enhancement of insulin-like growth factor signaling in human breast cancer:  Estrogen regulation of IRS-1 expression in vitro and in vivo.  Molecular Endocrinology, 13:787-96, 1999.

1998

Oesterreich S, Lee AV, Sullivan T, Samuel S.K., Davie, J.R. and Fuqua SAW. Novel nuclear matrix protein HET binds to and influences activity of the HSP7 promoter in human breast cancer cells.  Journal of Cell Biology, 67:275-286, 1997.

Gooch JL, Lee AV, and Yee D.  Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells. Cancer Research, 58:4199-4205, 1998.

Lee AV, Jackson JG, Gooch JL, Hilsenbeck SG, Osborne CK, Yee D.  Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells. Cancer Research, 58:4199-4205, 1998.

1997

Lee AV, Weng C-N, Jackson JG, Yee D. Activation of estrogen receptor mediated gene transcription by insulin-like growth factor-1 (IGF-1) in human breast cancer cells.  Journal of Endocrinology, 152:39-47, 1997.

Rocha R, Hilsenbeck SG, Jackson JG, Van Den Berg C, Weng C-N, Lee AV and Yee D.  Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer:  Correlation with clinical parameters and disease-free survival.  Clinical Cancer Research, 3:103-09, 1997.

Dong Q, Du H, Farris S, Kolakowski LF Jr, Lee AV, Mandarino LJ, Fan JB, Yee D, Liu F.  Cloning, chromosome localization, expression and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10alpha.  Journal of Biological Chemistry, 272:29014-29112, 1997.

Lee AV, Weng C-N, McGuire SE, Wolf DM and Yee D.  Lac repressor inducible gene expression in human breast cancer cells in vitro and in a xenograft tumor.  Biotechniques, 23:1062-1068, 1997.

1996

Rocha R, Hilsenbeck SG, Jackson JG, Lee AV, Figueroa JA, Yee D.  Correlation of insulin like growth factor binding protein-3 messenger RNA with protein expression in primary breast cancer tissues: detection of higher levels in tumors with poor prognostic features.  Journal of the National Cancer Institute, 88:601-06, 1996.

1995

Bartlett JMS, Rabiasz GJ, Scott WN, Langdon SP, Hirst GL, Lee AV, Smith JF, Miller WR. Growth control of human ovarian carcinoma cells by insulin-like growth factors.  Oncology Reports, 2:857-62, 1995.

Figueroa JA, Lee AV, Jackson JG, Yee D.  Proliferation of cultured human prostate cancer cells is inhibited by insulin-like growth factor binding protein-1. Evidence for an IGF-II autocrine growth loop. Journal of Clinical Endocrinology & Metabolism, 80:3476-82, 1995.

1994

Lee AV, Darbre P, King RJB. Processing of insulin-like growth factor II (IGF-II) by human breast cancer cells. Molecular and Cellular Endocrinology, 99:211-220, 1994.